pentobarbital will lessen the extent or influence of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Solid or moderate CYP3A4 inducers may raise amount of diazepam elimination; therefore, efficacy of diazepam can be decreased.pentobarbital will lower the level or impact of nisoldipine by impacting hepa