pentobarbital will lessen the extent or influence of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Solid or moderate CYP3A4 inducers may raise amount of diazepam elimination; therefore, efficacy of diazepam can be decreased.
pentobarbital will lower the level or impact of nisoldipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
fentanyl iontophoretic transdermal method and pentobarbital both boost sedation. Keep away from or Use Alternate Drug. Limit use to people for whom different treatment possibilities are insufficient
pentobarbital will decrease the extent or result of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Reserve concomitant prescribing of such drugs in sufferers for whom other remedy options are inadequate. Limit dosages and durations on the least required. Monitor closely for signs of respiratory despair and sedation.
pentobarbital will decrease the extent or effect of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or impact of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the extent or impact of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.
pentobarbital will decrease the level or result of temsirolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.
pentobarbital will lower the extent or result of sulfamethoxazole by impacting hepatic enzyme CYP2C9/ten metabolism. Small/Importance Not known.
This drug may possibly interfere Along read more with the absorption of orally administered griseofulvin, decreasing its blood concentrations; effects of blood stage reduction not known; preferable to stay away from concomitant administration of these medicines
Warning when discontinuing CYP3A4 inducers which can be coadministered with hydrocodone; plasma concentrations of hydrocodone may perhaps improve and may lead to possibly deadly respiratory despair
pentobarbital will lower the extent or impact of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.